Menogon 75 IU Injection

✔️ Uses of Menogon 75 IU Injection

• Female Infertility
• Male Infertility
• Male hypogonadism

✔️ How does Menogon 75 IU Injection work?

This medicine acts by stimulating and promoting the production of certain hormones in the ovary and testis

✔️ Side Effects of Menogon 75 IU Injection

• Injection site pain
• Fatigue
• Headache
• Stomach Pain
• Pain In The Lower Abdomen
• Infections
• Nausea Or Vomiting
• Rapid Weight Gain
• Allergic Skin Reaction
• Irritation
• Depression
• Restlessness

✔️ Quick Suggestions:

• Menogon 75 IU Injection stimulates the production of eggs in women undergoing treatment for infertility.
• It may also be used to stimulate sperm formation in men.
• Your doctor may prescribe more than one medicine as part of your suggested pregnancy plan.
• Pregnancy following treatment with Menogon Injection is more likely to result in a multiple pregnancy (twins or more) than if you had conceived naturally.
• Menogon 75 IU Injection is administered under the skin. Follow the recommended dosage and monitoring schedules to minimize the possibility of ovarian hyperstimulation.
• Inform your doctor immediately if you have severe pelvic pain, nausea, vomiting, diarrhea, sudden weight gain, trouble breathing, or decreased or no urination during treatment, as these could be symptoms of ovarian hyperstimulation syndrome (OHSS).
• Do not use Menogon Injection if you are already pregnant or breastfeeding.

✔️ Indication

Menogon 75 IU Injection serves multiple purposes in treating infertility:

1. Infertility Treatment: It addresses infertility in both men and women.
2. PCOD Treatment: In women with polycystic ovary syndrome (PCOS), it promotes the growth and release of eggs.
3. Egg Production: For women undergoing fertility treatments, it supports the production of multiple eggs.
4. Sperm Count Improvement: It enhances sperm count in men.

✔️ Pharmacology

Menogon Injection includes Menotrophin, a component with dual actions akin to both luteinizing hormone and follicle-stimulating hormone. This compound is employed in both men and women to enhance reproductive function. In females, it aids the release of eggs, while in males, it boosts sperm counts. This multifaceted approach improves overall reproductive capabilities.

✔️ Dosage & Administration of Menogon 75 IU Injection

Here are the recommended doses and guidelines for Menotropin (Follicle Stimulation) in various contexts:

Assisted Reproduction Technologies (ART):

• Initial dose: 225 International Units daily, administered subcutaneously (SC) or intramuscularly (IM).
• Menotropin can be combined with urofollitropin; the combined dose is not to exceed 225 International Units (e.g., 150 International Units menotropin and 75 International Units of urofollitropin).
• Maximum dose: 450 International Units daily.
• Duration: 7 to 20 days.
• Continue until adequate follicular development; administer human chorionic gonadotropin (hCG) for final follicular maturation.
• Withhold hCG if monitoring suggests an increased risk of ovarian hyperstimulation syndrome (OHSS).

Ovulation Induction:

• Initial dose: 150 International Units daily for the first 5 days.
• Maximum dose: 450 International Units daily.
• Duration: 7 to 12 days.
• If the patient's response is suitable, administer hCG one day after the last menotropin dose.
• If follicle development or ovulation is inadequate without pregnancy, treatment may be repeated.

Adjustments:

• Dosing should be individualized for each patient.
• Adjust dose based on the ovarian response, evaluated by follicular growth and estradiol levels (for assisted reproduction) or monitoring (serum estradiol and vaginal ultrasound) for ovulation induction.
• Do not make additional dose adjustments more frequently than every 2 days or by more than 150 International Units at each adjustment.

Male Infertility due to Hypogonadotropic Hypogonadism:

• Prior hCG treatment stimulates spermatogenesis.
• Start menotrophin at 75 or 150 IU 2-3 times weekly through SC or IM injection in combination with hCG.
• Continue for a minimum of 3-4 months.

Female Infertility of Anovulatory Origin:

• Initiate therapy within the first 7 days of the menstrual cycle in unresponsive cases (including polycystic ovarian disease).
• Begin with 75-150 IU daily through SC or IM injection for at least 7 days.
• Adjust doses based on individual response (monitored clinically and with ovarian ultrasound and serum estradiol measurement).
• Adjust in increments of 37.5 IU every 7 days, up to a maximum of 225 IU daily.
• If insufficient response after 3-4 weeks, restart treatment at a higher initial dose.
• Administer hCG 1 day after the final menotrophin dose with optimal response.

Controlled Ovarian Hyperstimulation for Assisted Reproduction:

• In GnRH antagonist protocol, initiate menotrophin on day 2 or 3 of the menstrual cycle.
• In GnRH agonist protocol, start menotrophin about 2 weeks after agonist treatment begins.
• Commence with 150-225 IU daily SC or IM injection for at least the initial 5 days.
• Adjust doses based on response (clinically monitored with ultrasound and serum estradiol measurement).
• Increase in up to 150 IU increments; max: 450 IU daily.
• Treatment duration: maximum 20 days.
• Administer hCG when an appropriate number of follicles are ready for oocyte retrieval.

Reconstitution:

• Dissolve vial content in provided diluent (0.9% NaCl injection).
• Swirl gently to dissolve; avoid shaking.

Administration:

• Menogon 75 IU Injection is administered by a doctor or nurse
• Your doctor will decide on your starting dose
• This dose may be adjusted during your treatment period and it varies according to your health condition and body weight

These guidelines are intended for the development of multiple follicles and pregnancy in ovulatory women using assisted reproductive technology or for ovulation induction in specific cases. Always consult a healthcare professional and refer to local guidelines for accurate dosing and management.

✔️ Interaction

Drug-Drug Interactions: It's not advisable to use Menogon 75 IU Injection alongside other infertility medications, like clomiphene citrate.

Drug-Food Interactions: Restrict alcohol consumption while using Menogon 75 IU Injection, as it could heighten the chances of side effects.

Drug-Disease Interactions: Be cautious when using Menogon 75 IU Injection if you have tumors, particularly in the uterus or testes. Use it cautiously in such cases.

✔️ Contraindications

Do not use Menogon Injection if you have:

• An allergy to menotrophin or any ingredient in the injection.
• A pituitary gland tumor.
• A tumor of the hypothalamus.
• Tumors in the uterus, ovaries, or breasts.
• Fluid-filled cysts in your ovaries not caused by PCOD.
• Observed unusual vaginal bleeding.
• Experienced premature menopause (menstrual periods stopping too early).
• Abnormalities in your reproductive organs (womb, fallopian tubes, ovaries, or cervix).
• Undergone a hysterectomy (womb removal).
• Non-cancerous womb tumors (fibroids).
• If you're pregnant or breastfeeding.
• Cancer of the prostate gland or testicles.

✔️ Pregnancy & Lactation

Pregnant women are advised not to use this medicine. Regarding breastfeeding, it's not recommended unless absolutely necessary. If you need to take this medicine while breastfeeding, take special precautions, and consider discontinuing breastfeeding during the treatment period. Consult your doctor to carefully weigh the risks and benefits before making a decision.

✔️ Precautions & Warnings

Avoid taking Menogon 75 IU Injection if you:

• Are allergic to it or its ingredients?
• Have tumors, especially in the uterus or breast. Inform your doctor if you're a female with these conditions.
• Have testes cancer.

For pregnant or nursing women, consult your doctor before using Menogon 75 IU Injection. It's not recommended for children.

Be cautious as Menogon 75 IU Injection might affect your driving ability, so avoid driving while using it.

Before using Menogon 75 IU Injection, inform your doctor if you:

• Have ovarian cysts.
• Experience unexplained vaginal bleeding.
• Have had a hysterectomy (uterus removal).

Additionally, notify your doctor if you experience symptoms like abdominal pain or swelling, nausea or vomiting, diarrhea, weight gain, breathing difficulties, or reduced urination.

✔️ Storage Conditions

• Store between 3-25°C. Do not freeze. Protect from light. Storage recommendations may vary among countries or individual products.
• Keep it out of the reach of children and pets.
• Discard any unused medicine